My research focuses on the cognitive and neural changes that occur in healthy aging and dementia. In particular, I am interested in the early detection of Alzheimer's disease, and the predictive roles of biomarkers (PET and MRI imaging, cerebrospinal fluid, genetic markers) in cognitive decline. Other ongoing work examines the influence of lifestyle factors such as cognitive stimulation on Alzheimer's disease and normal aging, and the impact of chemotherapy on neural and cognitive function.
I received a BA at Wesleyan University and a MA and PhD at the University of California, Berkeley, where my dissertation and postdoctoral work included research on working memory, practice and expertise, dopamine function and aging, and functional MRI scanning and image analysis.
SM Landau, A Horng A, A Fero, WJ Jagust (2016). Amyloid negativity in patients with clinically diagnosed Alzheimer disease and MCI. Neurology (online).
EE Sundermann, A Biegon, LH Rubin, RB Lipton, W Mowrey, SM Landau, PM Maki (2016). Better verbal memory in women than men in MCI despite similar levels of hippocampal atrophy. Neurology (online).
WJ Jagust, SM Landau, RA Koeppe, EM Reiman, K Chen, CA Mathis, JC Price, NL Foster, AY Wang (2015). The Alzheimer's Disease Neuroimaging Initiative 2 PET Core: 2015. Alzheimers & Dementia, 11, 757-771.
A Altmann, B Ng, SM Landau, WJ Jagust, MD Greicius (2015). Regional Brain Hypometabolism Is Unrelated to Regional Amyloid Plaque Burden. Brain (dx.doi.org/10.1093/brain/awv278).
S Schreiber, SM Landau, A Fero, F Schreiber, WJ Jagust (2015). Comparison of visual and quantitative florbetapir PET analysis in predicting MCI outcomes. JAMA Neurology, 72,1183-1190.
WJ Jagust, SM Landau, RA Koeppe, EM Reiman, K Chen, CA Mathis, JC Price, NL Foster, AY Wang (2015). The Alzheimer’s Disease Neuroimaging Initiative 2 PET Core: 2015. Alzheimers & Dementia, 11, 757-71.
SM Landau, A Fero, SL Baker, RA Koeppe, MA Mintun, K Chen, EM Reiman, WJ Jagust (2015). Measurement of longitudinal Aβ change with 18F florbetapir PET and standard uptake value ratios. J Nucl Med, 56, 567-74.
JB Toledo, M Bjerke, D Xiao, SM Landau, NL Foster, WJ Jagust, C Jack, M Weiner, C Davatzikos, LM Shaw, JQ Trojanowski (2015). Nonlinear Association Between Cerebrospinal Fluid and Florbetapir F-18 β-Amyloid Measures Across the Spectrum of Alzheimer Disease. JAMA Neurology, 72, 571-581.
A Caroli, A Prestia, S Wade, K Chen, N Ayutyanont, SM Landau, CM Madison, C Haense, K Herholz, EM Reiman, WJ Jagust, GB Frisoni (2015). Alzheimer Disease Biomarkers as Outcome Measures for Clinical Trials in MCI. Alzheimer’s Dis & Assoc Dis, 29, 101-109.
K Chen, A Roontiva, P Thiyyagura, W Lee, X Liu, N Ayutyanont, H Protas, J Luo, R Bauer, C Reschke, D Bandy, RA Koeppe, A Fleisher, R Caselli, SM Landau, WJ Jagust, M Weiner (2015). Improved power to characterize longitudinal amyloid-β PET changes and evaluate amyloid-modifying treatments using a cerebral white matter reference region. J Nucl Med, 56, 560-6.
N Mattsson, P Insel, M Donohue, SM Landau, WJ Jagust, L Shaw, J Trojanowski, H Zettererg, K Blennow, M Weiner (2015). Independent information from cerebrospinal fluid β-amyloid and florbetapir imaging in Alzheimer’s disease. Brain,138:772-83.
ME Schmidt, P Chiao, G Klein, D Matthews, L Thurfhell, PE Cole, R Margolin, SM Landau, NL Foster, NS Mason, S De Santi, J Suhy, RA Koeppe, WJ Jagust, (2014). The influence of biological and technical factors on quantitative analysis of amyloid PET: Points to consider and recommendations for controlling variability in longitudinal data. Alzheimer’s & Dementia (doi:10.1016/j.jalz.2014.09.004).
SM Landau, BA Thomas, L Thurfjell, M Schmidt, R Margolin, MA Mintun, M Pontecorvo, SL Baker, and WJ Jagust (2014). Amyloid PET imaging in Alzheimer’s disease: A comparison of three radiotracers. Eur J Nucl Med & Mol Img, 41,1398-1407.
M Wirth, S Villeneuve, CM Haase, CM Madison, H Oh, SM Landau, GD Rabinovici, WJ Jagust (2013). Alzheimer’s disease biomarkers, white matter lesion, and cognition in normal older people. JAMA Neurology (2013).
J Nettiksimmons, C DeCarli, SM Landau, L Beckett (2013). Biological heterogeneity in ADNI amnestic MCI. Alzheimer’s & Dementia (in press).
T Haight, SM Landau, O Carmichael, C Schwartz, C DeCarli, WJ Jagust (2013). Dissociable effects of Alzheimer's Disease and white matter hyperintensities on brain metabolism. JAMA Neurology (online June 17 2013).
KR Murphy, SM Landau, KR Choudhury, CA Hostage, KS Shpanskaya, HI Sair, JR Petrella, TZ Wong, PM Doraiswamy (2013). Mapping the effects of ApoE4, age and cognitive status on 18F-ﬂorbetapir PET measured regional cortical patterns of beta-amyloid density and growth. NeuroImage, 78, 474–480.
SM Landau, M Lu, AD Joshi, M Pontecorvo, MA Mintun, JQ Trojanowski, LM Shaw, WJ Jagust (2013). Comparing PET imaging and CSF measurements of Aß. Annals of Neurology, 10.1002/ana.23908.
M Wirth, C Madison, G Rabinovici, H Oh, SM Landau, and WJ Jagust (2013). Alzheimer's disease neurodegenerative biomarkers are associated with decreased cognitive function but not beta-amyloid in cognitively normal older individuals. J Neuroscience, 33, 5553-5563.
M Wirth, H Oh, EC Mormino, C Markley, SM Landau, WJ Jagust (2013). The effect of amyloid β on cognitive decline is modulated by neural integrity in cognitively normal elderly. Alzheimer’s & Dementia (online March 7 2013).
SM Landau, C Breault, AD Joshi, M Pontecorvo, CA Mathis, WJ Jagust, and MA Mintun (2013). Amyloid imaging with Pittsburgh compound B and florbetapir: Comparing radiotracers and quantification methods. J Nucl Medicine, 54, 70-77.
WJ Jagust & SM Landau (2012). Apolipoprotein E, not Fibrillar Beta-amyloid, Reduces Cerebral Glucose Metabolism in Normal Aging. J Neuroscience, 32, 18227-18227-18223.
SM Landau & M Doraiswamy (2012). The Biology of Alzheimer’s Disease (Book Review). JAMA, 308, 1925-1926.
SM Landau, MA Mintun, AD Joshi, RA Koeppe, RC Petersen, PS Aisen, MW Weiner, and WJ Jagust (2012). Amyloid deposition, hypometabolism, and longitudinal cognitive decline. Annals of Neurology, 72, 578-586.
A Caroli, A Prestia, K Chen, N Ayutyanont, SM Landau, CM Madison, C Haense, K Herholz, F Nobili, EM Reiman, WJ Jagust, GB Frisoni, EADC-PET Consortium, NEST-DD, and the Alzheimer’s Disease Neuroimaging Initiative (2012). Summary metrics to assess Alzheimer’s disease-related hypometabolic pattern with FDGPET: Head-to-head comparison. J Nucl Medicine, 53, 592-600.
SM Landau, SM Marks, EC Mormino, GD Rabinovici, H Oh, JP O’Neil, RS Wilson, WJ Jagust (2012). Lifetime cognitive engagement is associated with low beta-amyloid deposition. Archives of Neurology, 69, 623-629.
EC Klosterman, MN Braskie, SM Landau, JP O’Neil, WJ Jagust (2012). Dopamine synthesis capacity is related to front-striatal functional connectivity and task accuracy in older adults. Neurobiology of Aging, 33, 623.e15-623.e324.
K Chen, N Ayutyanont, JB Langbaum, AS Fleisher, C Reschke, W Lee, X Liu, D Bandy, GE Alexander, PM Thompson, L Shaw, JQ Trojanowski, CR Jack, SM Landau, NL Foster, DJ Harvey, MW Weiner, RA Koeppe, WJ Jagust, EM Reiman; Alzheimer's Disease Neuroimaging Initiative (2011). Characterizing Alzheimer’s disease using a hypometabolic convergence index. NeuroImage, 56, 52-60.
SM Landau, D Harvey, C Madison, NL Foster, EM Reiman, R Koeppe, MW Weiner, WJ Jagust, and the Alzheimer’s Disease Neuroimaging Initiative (2011). Cognitive, functional, and metabolic decline in Alzheimer’s disease and MCI. Neurobiology of Aging,32,1207-1218.
MN Braskie, SM Landau, CE Wilcox, SD Taylor, JP O’Neil, SL Baker, CM Madison, WJ Jagust (2011). Correlations of striatal dopamine synthesis with default network deactivations during working memory in younger adults. Human Brain Mapping, 32, 947-961.
SM Landau, D Harvey, C Madison, EM Reiman, NL Foster, GE Alexander, RC Peterson, LM Shaw, JQ Trojanowski, MW Weiner, WJ Jagust, and the Alzheimer’s Disease Neuroimaging Initiative (2010). Comparing predictors of conversion and decline in mild cognitive impairment. Neurology, 75, 230-238.
WJ Jagust, D Bandy, K Chen, NL Foster, SM Landau, C Mathis C, J Price, EM Reiman, D Skovronsky, R Koeppe, and the Alzheimer’s Disease Neuroimaging Initiative (2010). The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core. Alzheimer’s and Dementia, 6, 221-229.
WJ Jagust, SM Landau, LM Shaw, JQ Trojanowski, RA Koeppe, EM Reiman, NL Foster, RC Petersen, MW Weiner, JC Price, CA Mathis, and the Alzheimer’s Disease Neuroimaging Initiative (2009). Relationships between biomarkers in aging and dementia. Neurology, 73,1193-9.
SM Landau, R Lal, JP O’Neil, S Baker, WJ Jagust (2009). Striatal dopamine and working memory maintenance. Cerebral Cortex, 19, 445-454.
MN Braskie, CE Wilcox, SM Landau, JP O’Neil, SL Baker, CM Madison, JT Kluth, WJ Jagust (2008). Relationship of Striatal dopamine synthesis capacity to age and cognition. Journal of Neuroscience, 28, 14320-14328.
SM Landau, H Garavan, EH Schumacher, M D’Esposito (2007). Regional specificity and practice: Dynamic changes in object and spatial working memory. Brain Research, 1180,78-89.
SM Landau and M D’Esposito (2006). Sequence learning in pianists and non-pianists: An fMRI study of motor expertise. Cognitive, Affective, and Behavioral Neuroscience, 6, 246-259.
SM Landau, EH Schumacher, H Garavan, TJ Druzgal, M D’Esposito (2004). A functional MRI study of the influence of practice on component processes of working memory. NeuroImage, 22, 211-221.